MONIPA
Gain real-time insights into your downstream processes with inline monitoring. Capture continuous data in under a minute, ensuring rapid detection of process variations. Optimize efficiency, maintain consistency, and enhance quality control without interrupting your processes.
ABOUT MONIPA
Monipa introduces a plug-and-play solution for spectroscopy and is implemented inline into downstream bioprocesses for mRNA and mAb process development.
At its core is a mid-infrared spectrometer with a spectral range of 900–4,000 cm⁻¹, encompassing the critical fingerprint region for the analysis of biological molecules. It features a dismountable, single-use flow cell, offering flexibility for various applications. Combined with our user-friendly software, we make spectroscopy accessible and effortless for our biopharma customers, empowering fast and reliable process development.
Our single-use flow cell
IRUBIS’ single-use flow cell is designed with a screw mechanism to enable easy and stable fixation. After each monitored process, it is replaced to prevent contamination risk. By connecting the flow cell inline via loop to e.g. Ultra-/Diafiltration (UF/DF), different parameters can be monitored. By regulating flow and minimizing disruptions, our flow cell ensures stable and continuous measurement conditions.
User-friendly software
Monipa comes with a software that features an effortless calibration model, simplifying spectroscopy and making it easy to use for everyone. It is seamlessly connected your system through OPC UA, RESTful API, and Ethernet. Raw spectral data is visualized in real-time, and you can download it in multiple formats. With direct output of monitored parameters over time, tracking and analyzing results is fast and flexible.
No Calibration Model Building
Calibration model building is an important step for spectroscopic devices. The spectra depends on the molecules in the measured samples. Following this, also different cell lines, cell culture media, metabolite or nutrient concentration leads to changes in the spectra. Calibration models are built by correlating the spectroscopic measurements to the reference method. IRUBIS’ real-time monitoring solution, Monipa, offers an innovative approach to solve the time extensive and costly calibration model building. Our effortless calibration method is based on a relative measurement. Only the known start-value of the parameter need to be included. Consequently the measurement of reference processes for calibration model building are not necessary.
