MONIPA
Monipa captures continuous bioprocess data in under a minute to enable rapid detection of process deviations, improved efficiency and enhanced quality control—all without interruption and delays. Integrate Monipa into your downstream operations to unlock intelligent insights and move closer to fully automated, in-process control.
ABOUT MONIPA
It is a plug-and-play tool with single-use capabilities, designed for inline integration into mAb and DNA/RNA downstream bioprocess monitoring.
At its core is a mid-infrared spectrometer with a spectral range of 900–4,000 cm⁻¹, encompassing the critical fingerprint region for the analysis of biological molecules. It features a dismountable, single-use flow cell, offering flexibility for various applications. Combined with our user-friendly software, we make spectroscopy accessible and effortless for our biopharma customers, empowering fast and reliable process development.
Our single-use flow cell
The IRUBIS single-use flow cell is designed with a screw mechanism for easy and stable fixation. After each run, it is replaced to prevent the risk of cross-contamination. Connected inline via a loop to processes such as Ultra-/Diafiltration (UF/DF), the flow cell enables simultaneous monitoring of multiple parameters. Its design ensures controlled flow and minimal disruption, providing stable and continuous measurement conditions.
User-friendly software
Monipa includes intuitive software with a built-in calibration model, making spectroscopy simple and accessible for all users. It is seamlessly connected your system through OPC UA, RESTful API, and Ethernet. Raw spectral data is visualized in real-time, and can be exported in multiple formats. With direct output of monitored parameters over time, our software enables fast, flexible tracking and analysis.
No Calibration Model Required
Calibration model building is a critical step for spectroscopic devices, as the spectra depend on the molecular composition of the sample. Variations in cell lines, culture media, and metabolite or nutrient concentrations all influence spectral output. Traditional models require extensive reference measurements to correlate spectroscopic data with standard methods — a time-consuming and costly process.
Monipa introduces an innovative and simplified approach: a relative calibration method that requires only the known starting value of the parameter. This eliminates the need for measuring multiple reference processes, significantly reducing the time and resources required for calibration.
