Analytical performance of μ-groove silicon attenuated total reflection waveguides
Authors: J Haas, A Müller, L Sykora,B Mizaikoff
The analytical performance of micromachined μ-groove silicon ATR elements has been evaluated in a comparison of FTIR and QCL spectroscopy operating at MIR wavelengths. μ-Groove silicon ATR elements are highly efficient micromachined waveguides fabricated at a wafer scale at such low cost that they may be considered a consumable for single-time-use, e.g., in medical application scenarios. Herein, exemplary analytes haven been used for reliably evaluating their analytical performance (i.e., acetate and carbonate) in terms of sensitivity, noise level, and achievable limits of detection in a comparison of broadband vs. narrowband infrared spectroscopy.
Hybrid Gold–Conductive Metal Oxide Films for Attenuated Total Reflectance Surface Enhanced Infrared Absorption Spectroscopy
Authors: I R Andvaag, T A Morhart, O J R Clarke, I J Burgess
The use of conductive metal oxide (CMO) films as supporting layers for ATR-SEIRAS is treated theoretically and experimentally. The greater mid-infrared transparency of thin layers of indium zinc oxide (IZO), as compared to metals, is verified through IR reflectivity measurements and the Drude model. IZO layers sputtered on our Specialized 1 ATR Crystals are found to have a thin surface layer with slightly different plasma frequency and electronic scattering time compared to the bulk material.
Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) Spectromicroscopy Using Synchrotron Radiation and Micromachined Silicon Wafers for Microfluidic Applications
Authors: T Morhart, S Read, G Wells, M Jacobs, S Rosendahl, S Achenbach, I J Burgess
This paper describes a custom-designed optical configuration for ATR FT-IR spectroscopy and imaging applications in microfluidic devices, compatible with the IRUBIS ATR Crystals. Results show that our crystals are highly compatible with standard photolithographic techniques. ATR FT-IR mapping as a function of sample position across the channel illustrates the potential application of this approach for rapid prototyping of microfluidic devices.
Parasites under the Spotlight: Applications of Vibrational Spectroscopy to Malaria Research
Authors: D Perez-Guaita, K M Marzec, A Hudson, C Evans, T Chernenko, C Matthäus, M Miljkovic, M Diem, P Heraud, J S Richards, D Andrew, D A Anderson, C Doerig, J Garcia-Bustos, D McNaughton, B R Wood
Infrared spectroscopy can be used as an anlytical method for biofluids. One application is the diagnosis of malaria.
The analysis of biofluids with IR is always a question of hygiene. Using our Universal ATR Crystals as a cost-effective and disposable alternative to diamonds enables many new applications.
Electrochemical ATR-SEIRAS Using Low-Cost, Micromachined Si Wafers
Authors: T A Morhart, B Unni, M J Lardner, I J Burgess
Researchers from Canada used our Universal ATR Crystals for electrochemical ATR Surface Enhanced Infrared Absorption Spectroscopy. If you are interested in this application, we now also offer the Specialized 1, an ATR Crystals optimized for applications like SEIRAS.
Subwavelength Structures for Interference Enhanced Attenuated Total Reflection Spectroscopy and its Application for Blood Analysis
Authors: L Sykora, A Müller, A Roth, S Kondratiev
Attenuated total reflectance (ATR) infrared absorption spectroscopy is a well-established analytical method. However, the sensitivity is limited compared to transmission measurements by the penetration depth of the evanescent wave. Innovative ATR Crystals with subwavelength pillars were made from silicon. First experiments show an enhancement factor of up to 20 compared to a standard single reflection diamond ATR element.
Workshop FT-IR Spectroscopy in Microbiological and Medical Diagnostics, 2017
ATR-FTIR Microplate Reader and Micromachined ATR Silicon Crystals
Authors: L Sykora, A Müller
The analysis of blood samples by Fourier Transform Infrared (FTIR) Spectroscopy to detect diseases like cancer or malaria are an upcoming topic in the last decades. There are ongoing efforts to transfer infrared spectroscopy from research into clinics.
Spectroscopy Solutions for Materials Analysis, 2018 (p. 52)
Automated ATR for High-Throughput Laboratories
New innovations in ATR elements in conjunction with an automated
optical platform has made automated ATR measurements possible.
Using the AutoATR, spectral results are more sensitive than a typical
single reflection ATR.
An Innovative Breakthrough in Automated ATR Sampling
Automating spectroscopic sampling delivers benefits to chemists and laboratory technicians by speeding the development of routine calibrations, reducing monotonous tasks and increasing efficiency and output. Read more about the benefits of AutoATR in this article.