Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) Spectromicroscopy Using Synchrotron Radiation and Micromachined Silicon Wafers for Microfluidic Applications
Authors: T Morhart, S Read, G Wells, M Jacobs, S Rosendahl, S Achenbach, I J Burgess
This paper describes a custom-designed optical configuration for ATR FT-IR spectroscopy and imaging applications in microfluidic devices, compatible with the IRUBIS ATR Crystals. Results show that our crystals are highly compatible with standard photolithographic techniques. ATR FT-IR mapping as a function of sample position across the channel illustrates the potential application of this approach for rapid prototyping of microfluidic devices.
Parasites under the Spotlight: Applications of Vibrational Spectroscopy to Malaria Research
Authors: D Perez-Guaita, K M Marzec, A Hudson, C Evans, T Chernenko, C Matthäus, M Miljkovic, M Diem, P Heraud, J S Richards, D Andrew, D A Anderson, C Doerig, J Garcia-Bustos, D McNaughton, B R Wood
Infrared spectroscopy can be used as an anlytical method for biofluids. One application is the diagnosis of malaria.
The analysis of biofluids with IR is always a question of hygiene. By reducing the price of our Single Reflection ATR Crystals, they can be used as disposables – enabling many new applications.
Subwavelength Structures for Interference Enhanced Attenuated Total Reflection Spectroscopy and its Application for Blood Analysis
Authors: L Sykora, A Müller, A Roth, S Kondratiev
Attenuated total reflectance (ATR) infrared absorption spectroscopy is a well-established analytical method. However, the sensitivity is limited compared to transmission measurements by the penetration depth of the evanescent wave. Innovative ATR Crystals with subwavelength pillars were made from silicon. First experiments show an enhancement factor of up to 20 compared to a standard single reflection diamond ATR element.
Workshop FT-IR Spectroscopy in Microbiological and Medical Diagnostics, 2017
ATR-FTIR Microplate Reader and Micromachined ATR Silicon Crystals
Authors: L Sykora, A Müller
The analysis of blood samples by Fourier Transform Infrared (FTIR) Spectroscopy to detect diseases like cancer or malaria are an upcoming topic in the last decades. There are ongoing efforts to transfer infrared spectroscopy from research into clinics.
Spectroscopy Solutions for Materials Analysis, 2018 (p. 52)
Automated ATR for High-Throughput Laboratories
New innovations in ATR elements in conjunction with an automated
optical platform has made automated ATR measurements possible.
Using the AutoATR, spectral results are more sensitive than a typical
single reflection ATR.
An Innovative Breakthrough in Automated ATR Sampling
Automating spectroscopic sampling delivers benefits to chemists and laboratory technicians by speeding the development of routine calibrations, reducing monotonous tasks and increasing efficiency and output. Read more about the benefits of AutoATR in this article.